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Hydroxyzine pamoate is an oral prescription form of hydroxyzine supplied in capsule strengths equivalent to 25 mg, 50 mg, or 100 mg of hydroxyzine hydrochloride. Current labeling includes anxiety and tension, itching from allergic conditions, and sedation before or after general anesthesia.
read more about hydroxyzine pamoate ...Hydroxyzine pamoate contains hydroxyzine in a pamoate salt form. The active hydroxyzine component has central nervous system and antihistaminic activity. Current labeling also describes skeletal muscle relaxing, bronchodilator, analgesic, and antiemetic effects.
Hydroxyzine pamoate capsules are used for symptomatic relief of anxiety and tension, management of itching associated with chronic urticaria and atopic or contact dermatoses, and sedation surrounding general anesthesia. Long-term antianxiety use beyond four months has not been systematically assessed.
Adult anxiety dosing is 50 mg to 100 mg four times daily. Adult pruritus dosing is 25 mg three or four times daily. Sedation before or after general anesthesia uses 50 mg to 100 mg in adults. Pediatric dosing varies by age and indication.
Hydroxyzine pamoate can cause drowsiness and can intensify central nervous system depression from alcohol, opioids, barbiturates, and related medicines. QT prolongation and torsades de pointes have been reported. A prolonged QT interval, early pregnancy, and hypersensitivity to hydroxyzine or related cetirizine compounds are contraindications.
It is used for anxiety and tension, allergic itching, and sedation around general anesthesia.
Current capsules are supplied in strengths equivalent to 25 mg, 50 mg, or 100 mg of hydroxyzine hydrochloride.
Current labeling lists 50 mg to 100 mg four times daily for symptomatic relief of anxiety and tension.
Yes. QT prolongation and torsades de pointes have been reported.
DailyMed - HYDROXYZINE PAMOATE capsule. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c0f7f48d-e39c-4981-9c0e-5c2eccaba424. Date Accessed October 1, 2026.
Hydroxyzine. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548128/. Date Accessed October 1, 2026.
Hydroxyzine. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a682866.html. Date Accessed October 1, 2026.
Hydroxyzine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Hydroxyzine. Date Accessed October 1, 2026.
Hydroxyzine Pamoate. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Hydroxyzine-pamoate. Date Accessed October 1, 2026.