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Hydrochlorothiazide and triamterene is a prescription diuretic combination. Hydrochlorothiazide increases sodium and water excretion, while triamterene reduces potassium loss in the distal renal tubule. Current tablets contain 37.5 mg/25 mg or 75 mg/50 mg of triamterene and hydrochlorothiazide.
read more about hydrochlorothiazide and triamterene ...Hydrochlorothiazide blocks renal tubular sodium and chloride reabsorption and increases urine production. Triamterene acts in the distal renal tubule to reduce sodium reabsorption in exchange for potassium and hydrogen. This potassium-conserving action counteracts excessive potassium loss associated with hydrochlorothiazide.
The combination treats hypertension or edema in patients who develop low potassium with hydrochlorothiazide alone or in patients where low potassium creates added clinical risk. It is not routine initial therapy for hypertension or edema except when development of hypokalemia cannot be risked.
The usual dose of the 37.5 mg/25 mg tablet is one or two tablets once daily. The usual dose of the 75 mg/50 mg tablet is one tablet once daily. Higher daily amounts have not been established in current labeling. Serum potassium is monitored during treatment.
Hyperkalemia can be fatal and is more common with kidney impairment, diabetes, older age, or severe illness. The combination is contraindicated with elevated potassium, anuria, significant kidney impairment, and other potassium-conserving medicines. Other concerns include electrolyte abnormalities, acute angle-closure glaucoma, kidney function changes, and hypersensitivity.
It treats hypertension or edema when hydrochlorothiazide alone causes low potassium or when low potassium creates added risk.
The usual dose is one or two tablets once daily.
Triamterene reduces potassium excretion and can cause dangerous hyperkalemia.
No. Current labeling contraindicates use with other potassium-conserving agents such as spironolactone or amiloride.
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Hydrochlorothiazide; Triamterene. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Hydrochlorothiazide%3B-Triamterene. Date Accessed October 1, 2026.
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