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Hydrochlorothiazide and irbesartan is a prescription fixed-dose combination used to treat hypertension. Irbesartan is an angiotensin II receptor blocker and hydrochlorothiazide is a thiazide diuretic. Current tablet strengths include 150 mg/12.5 mg, 300 mg/12.5 mg, and 300 mg/25 mg.
read more about hydrochlorothiazide and irbesartan ...Irbesartan blocks angiotensin II at the AT1 receptor, reducing vasoconstriction and aldosterone-related effects. Hydrochlorothiazide reduces sodium and chloride reabsorption in the distal renal tubule and increases urinary sodium and water excretion. Their blood pressure lowering effects are additive.
The combination treats adults with hypertension, including patients whose blood pressure is not adequately controlled with either component alone. It can also be used as initial therapy when combination treatment is appropriate. Severe kidney impairment with creatinine clearance below 30 mL per minute is a reason to avoid this product.
A usual starting dose is 150 mg irbesartan with 12.5 mg hydrochlorothiazide once daily. The dose can increase after one to two weeks to a maximum of 300 mg/25 mg once daily when further blood pressure reduction is needed. Tablets can be taken with or without food.
The combination carries a boxed warning for fetal toxicity and is stopped when pregnancy is detected. Other concerns include low blood pressure, impaired kidney function, electrolyte and metabolic abnormalities, acute angle-closure glaucoma, hypersensitivity, and increased blood glucose or uric acid. Aliskiren is contraindicated in patients with diabetes.
The combination treats hypertension in adults.
A usual starting dose is 150 mg irbesartan with 12.5 mg hydrochlorothiazide once daily.
The maximum labeled dose is 300 mg irbesartan with 25 mg hydrochlorothiazide once daily.
Yes. The boxed warning concerns fetal toxicity from medicines that act directly on the renin-angiotensin system.
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