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Humulin N is insulin isophane human, also called NPH insulin. It is an intermediate-acting human insulin used to improve glycemic control in adults and pediatric patients with diabetes mellitus. Current U.S. presentations contain 100 units per mL in vials and KwikPen devices.
read more about humulin n ...Humulin N lowers blood glucose by increasing glucose uptake in skeletal muscle and fat and by decreasing glucose production in the liver. It also reduces lipolysis and proteolysis and increases protein synthesis. Its action starts more slowly and lasts longer than regular human insulin.
Humulin N is used in adults and children with diabetes mellitus when intermediate-acting basal insulin is part of the treatment plan. It is injected only into subcutaneous tissue and can be used with a meal-time insulin when clinically indicated.
The dose is individualized according to metabolic needs, blood glucose results, and glycemic goals. Dose changes can be needed with changes in meals, physical activity, kidney or liver function, acute illness, or other medicines. Humulin N is not given intravenously and is not used in an insulin pump.
Hypoglycemia is the most common serious insulin-related risk and can cause seizures, loss of consciousness, or death. Other concerns include hypokalemia, severe hypersensitivity, medication errors, lipodystrophy, localized cutaneous amyloidosis, and fluid retention or heart failure when used with thiazolidinediones.
Humulin N is an intermediate-acting NPH human insulin.
No. Humulin N is administered only by subcutaneous injection.
No. Current labeling states that Humulin N is not used in insulin pumps.
Insulin needs vary with glucose results, meals, activity, illness, kidney or liver function, and other medicines.
DailyMed - HUMULIN N (insulin isophane human) injection, suspension. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f6edd793-440b-40c2-96b5-c16133b7a921. Date Accessed October 1, 2026.
Human Insulin Injection. MedlinePlus. https://medlineplus.gov/druginfo/meds/a682611.html. Date Accessed October 1, 2026.
HUMULIN N (insulin isophane human) Prescribing Information. Eli Lilly and Company. https://pi.lilly.com/us/HUMULIN-N-USPI.pdf. Date Accessed October 1, 2026.
Insulin. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK560688/. Date Accessed October 1, 2026.
Insulin Human. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Insulin-human. Date Accessed October 1, 2026.