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What Is Humalog?

Humalog is a rapid-acting insulin analog containing insulin lispro. It is indicated to improve glycemic control in adults and pediatric patients with diabetes mellitus. Current presentations include U-100 and U-200 strengths, with device and route restrictions that differ by presentation.

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What Is Humalog?

Humalog is a rapid-acting insulin analog containing insulin lispro. It is indicated to improve glycemic control in adults and pediatric patients with diabetes mellitus. Current presentations include U-100 and U-200 strengths, with device and route restrictions that differ by presentation.

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How Does Humalog Lower Blood Glucose?

Insulin lispro lowers blood glucose by increasing glucose uptake in skeletal muscle and fat and by reducing glucose production in the liver. It also reduces lipolysis and proteolysis and increases protein synthesis. Its subcutaneous action begins faster and lasts for a shorter period than regular human insulin.

Who Is Treated With Humalog?

Humalog is used in adults and children with diabetes mellitus when rapid-acting insulin is part of the treatment plan. U-100 can be given by subcutaneous injection, selected insulin pumps, or intravenous administration in a monitored clinical setting. U-200 is used only by subcutaneous injection from its prefilled pen.

How Is Humalog Dosed?

Humalog dosing is individualized according to metabolic needs, blood glucose results, meals, activity, and other diabetes medicines. Subcutaneous U-100 or U-200 is injected within 15 minutes before a meal or immediately after a meal. U-100 used in an insulin pump follows the pump manufacturer's instructions.

What Serious Risks Are Linked to Humalog?

Hypoglycemia is the most common serious insulin-related risk and can be life-threatening. Other concerns include hypokalemia, severe hypersensitivity, medication errors, lipodystrophy, localized cutaneous amyloidosis, and fluid retention with thiazolidinediones. Pump malfunction can rapidly cause hyperglycemia and ketoacidosis.

Frequently Asked Questions About Humalog

What type of insulin is Humalog?

Humalog is a rapid-acting insulin analog containing insulin lispro.

When is Humalog injected around meals?

Subcutaneous Humalog is injected within 15 minutes before a meal or immediately after a meal.

Can Humalog U-200 be used in an insulin pump?

No. Humalog U-200 is not used in insulin pumps and is not transferred from the prefilled pen into a syringe.

Can Humalog cause low potassium?

Yes. Insulin can shift potassium into cells and cause hypokalemia, which can become serious.

References

DailyMed - HUMALOG (insulin lispro) injection, solution. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c8ecbd7a-0e22-4fc7-a503-faa58c1b6f3f. Date Accessed October 1, 2026.

HUMALOG (insulin lispro) Prescribing Information. Eli Lilly and Company. https://uspl.lilly.com/humalog/humalog.html?s=pi. Date Accessed October 1, 2026.

Insulin. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK560688/. Date Accessed October 1, 2026.

Insulin Lispro. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Insulin-Lispro. Date Accessed October 1, 2026.

Insulin Lispro Injection. MedlinePlus. https://medlineplus.gov/druginfo/meds/a697021.html. Date Accessed October 1, 2026.