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Hiprex is a prescription methenamine hippurate product. Each tablet contains 1 g of methenamine hippurate. It is indicated for prophylactic or suppressive treatment of frequently recurring urinary tract infections when long-term therapy is needed, after the active infection has been eradicated with other appropriate antimicrobial treatment.
read more about hiprex ...In acidic urine, methenamine is broken down to formaldehyde, which has antibacterial activity. The hippurate component also contributes to urinary acidity and has some antibacterial activity. Adequately acidic urine is needed for activity against certain urea-splitting organisms.
Hiprex is used for prophylactic or suppressive treatment of recurrent bacterial urinary tract infections after the active infection has been cleared. It is not a substitute for appropriate treatment of an active acute infection. Urine culture and urinary pH can be used to assess treatment and the need for urinary acidification.
Adults and patients older than 12 years take 1 g twice daily, in the morning and at night. Patients age 6 to 12 take 0.5 g to 1 g twice daily. Alkalinizing foods and medicines are restricted when needed, and additional urinary acidification can be used according to urinary pH and clinical response.
Hiprex is contraindicated in renal insufficiency, severe hepatic insufficiency, and severe dehydration. Methenamine products are not used with sulfonamides due risk of an insoluble precipitate forming in the urine. Very high methenamine doses have caused bladder irritation, painful and frequent urination, albuminuria, and visible blood in the urine.
Hiprex is used for long-term prophylactic or suppressive treatment of recurrent urinary tract infections after an active infection has been eradicated.
The labeled adult dose is 1 g twice daily, taken in the morning and at night.
Methenamine forms antibacterial formaldehyde in acidic urine, so adequate urinary acidity is needed for its action.
No. Methenamine products are not used with sulfonamides due the risk of insoluble precipitate formation in the urine.
DailyMed - HIPREX (methenamine hippurate) tablet. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c8ddaa11-5753-46eb-8bd4-8f1d874a3ec4. Date Accessed October 1, 2026.
DailyMed - METHENAMINE HIPPURATE tablet. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4412d667-63f6-427e-a5c6-376a0e1e172d. Date Accessed October 1, 2026.
Evidence Review for the Effectiveness of Methenamine Hippurate in the Prevention of Recurrent Urinary Tract Infections. NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK611955/. Date Accessed October 1, 2026.
Methenamine. MedlinePlus. https://medlineplus.gov/druginfo/meds/a682296.html. Date Accessed October 1, 2026.
Methenamine Hippurate. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/21945. Date Accessed October 1, 2026.