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Harvoni is a prescription antiviral combination of ledipasvir and sofosbuvir. It treats certain chronic hepatitis C infections, including genotypes 1, 4, 5, and 6 under the conditions listed in its label. It is approved for adults and children aged 3 years and older.
read more about harvoni ...Ledipasvir and sofosbuvir block different proteins that hepatitis C virus needs to multiply. Using them together can clear the virus from the body. The prescribed treatment length depends on the virus genotype, liver condition, and treatment history.
Harvoni is taken by mouth once daily, with or without food. Tablets and oral pellets are available, with pediatric dosing based on weight. Take every dose as prescribed and follow the full treatment plan.
Headache and tiredness are reported side effects. Tell your clinician about side effects that are severe or persistent. If Harvoni is prescribed with ribavirin, additional precautions and side effects apply.
Your clinician should test for current or past hepatitis B before treatment, since hepatitis B can reactivate during or after hepatitis C therapy. Amiodarone taken with Harvoni can cause a dangerously slow heart rate. Antacids and other acid-reducing medicines can also affect ledipasvir, so review all medicines with your pharmacist.
Harvoni contains ledipasvir and sofosbuvir. Both act against hepatitis C virus.
Its label includes genotypes 1, 4, 5, and 6 in specified clinical circumstances. Your clinician will check your genotype and liver status before choosing treatment.
It is approved for certain children aged 3 years and older. Their dose depends on body weight.
Past or current hepatitis B can reactivate during or after hepatitis C treatment. Screening helps your clinician plan monitoring and care.
HARVONI (ledipasvir and sofosbuvir) tablets and oral pellets: Prescribing Information. DailyMed (National Library of Medicine). https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f4ec77e4-bae8-4db0-b3d5-bde09c5fa075. Date Accessed October 6, 2026.
Harvoni Patient Drug Record. NIH HIVinfo. https://clinicalinfo.hiv.gov/en/drugs/ledipasvirsofosbuvir/patient. Date Accessed October 6, 2026.
Ledipasvir and Sofosbuvir. MedlinePlus. https://medlineplus.gov/druginfo/meds/a614051.html. Date Accessed October 6, 2026.
Ledipasvir and sofosbuvir (oral route) - Side effects & dosage. Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/ledipasvir-and-sofosbuvir-oral-route/description/drg-20122589. Date Accessed October 6, 2026.
Ledipasvir Sofosbuvir Tablets: Uses & Side Effects. Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/18043-ledipasvir-sofosbuvir-tablets. Date Accessed October 6, 2026.