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What Is Gvoke HypoPen?

Gvoke HypoPen is a ready-to-use glucagon auto-injector for severe low blood sugar. It is prescribed for people with diabetes who are at least 2 years old. It is intended for situations when a person needs help treating severe hypoglycemia.

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What Is Gvoke HypoPen?

Gvoke HypoPen is a ready-to-use glucagon auto-injector for severe low blood sugar. It is prescribed for people with diabetes who are at least 2 years old. It is intended for situations when a person needs help treating severe hypoglycemia.

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How Gvoke HypoPen Works

Glucagon prompts the liver to release stored glucose into the blood. This raises blood sugar during a severe hypoglycemic episode. Its action can be limited when the liver has too little stored glucose.

How to Use Gvoke HypoPen

Inject it under the skin of the lower abdomen, outer thigh, or outer upper arm according to its instructions. Call emergency services immediately after giving the injection. Once the person has responded and can safely swallow, give oral carbohydrates.

Possible Side Effects

Nausea and vomiting can occur after glucagon is given. The person may still need medical care even if they wake up. Tell the treating team about the severe low blood sugar episode so the diabetes plan can be reviewed.

Keeping an Auto-Injector Ready

Caregivers should know where the HypoPen is kept and how to use it before an emergency occurs. Check its expiration date and inspect the medicine as directed. Each HypoPen contains one dose and must not be reused.

Frequently Asked Questions About Gvoke HypoPen

When is Gvoke HypoPen used?

It is used for severe low blood sugar in a person with diabetes. Give it according to the device instructions and call emergency services right away.

Can Gvoke HypoPen be used for children?

It is indicated for children aged 2 years and older. The prescribed strength for a child depends on age and weight.

What if the person does not respond after 15 minutes?

The label permits another dose from a new device while awaiting emergency help. Follow the prescribed emergency plan.

Should food be given immediately after the injection?

Give oral carbohydrates after the person responds and can safely swallow. Do not give food or drink by mouth to someone who cannot swallow safely.

References

Glucagon. StatPearls (NCBI Bookshelf). https://www.ncbi.nlm.nih.gov/books/NBK559195/. Date Accessed October 6, 2026.

Glucagon (injection route) - Side effects & dosage. Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/glucagon-injection-route/description/drg-20064089. Date Accessed October 6, 2026.

Glucagon Injection. MedlinePlus. https://medlineplus.gov/druginfo/meds/a682480.html. Date Accessed October 6, 2026.

GVOKE (glucagon) injection: Prescribing Information. DailyMed (National Library of Medicine). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=92385737-dbad-98c5-e053-2995a90a2805. Date Accessed October 6, 2026.

GVOKE HypoPen (glucagon injection): Instructions for Use. Xeris Pharmaceuticals. https://www.gvokeglucagon.com/wp-content/uploads/2023/07/instructions-for-use-gvoke-hypopen.pdf. Date Accessed October 6, 2026.