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Glucosamine is a substance found in the body that helps form components of cartilage. It is sold in the U.S. as a dietary supplement, commonly as glucosamine sulfate or glucosamine hydrochloride. Products may contain glucosamine alone or combine it with chondroitin.
read more about glucosamine ...People commonly take glucosamine supplements for knee osteoarthritis symptoms. Studies of pain and joint function have produced inconsistent results. Research has not established that glucosamine reliably rebuilds cartilage or prevents joint damage.
Glucosamine is a building block for molecules that form part of cartilage. This role led researchers to study whether supplements could affect osteoarthritis symptoms or joint structure. A dependable benefit from taking it as a supplement has not been established.
Glucosamine is sold in tablets, capsules, and other oral supplement forms. Ingredients and directions differ by product, so check the label. Discuss it with a clinician if you have diabetes, take prescription medicines, or are considering it for persistent joint pain.
Large osteoarthritis studies have not identified major safety problems, but glucosamine may raise blood sugar in some people. It has been linked to increased bleeding risk in people taking warfarin. Its safety during pregnancy and breastfeeding is uncertain.
Research results for pain and function are inconsistent. A clear benefit has not been established.
Studies have not shown a reliable improvement in joint structure. Glucosamine should not be viewed as a way to regrow cartilage.
It may raise blood sugar in some people. People with diabetes should discuss its use with their care team.
Ask the warfarin prescriber first. The combination has been associated with an increased risk of bleeding.
Glucosamine. Mayo Clinic. https://www.mayoclinic.org/drugs-supplements-glucosamine/art-20362874. Date Accessed October 6, 2026.
Glucosamine and Chondroitin for Osteoarthritis. National Center for Complementary and Integrative Health. https://www.nccih.nih.gov/health/glucosamine-and-chondroitin-for-osteoarthritis-what-you-need-to-know. Date Accessed October 6, 2026.
Glucosamine: Does it protect cartilage in osteoarthritis? Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/osteoarthritis/expert-answers/glucosamine/faq-20058430. Date Accessed October 6, 2026.
Is glucosamine effective for osteoarthritis? PubMed. https://pubmed.ncbi.nlm.nih.gov/28306711/. Date Accessed October 6, 2026.
Osteoarthritis: In Depth. National Center for Complementary and Integrative Health. https://www.nccih.nih.gov/health/osteoarthritis-in-depth. Date Accessed October 6, 2026.