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Gabapentin enacarbil is a prescription medicine sold as the extended-release product Horizant. The body converts it to gabapentin after it is absorbed. It has different dosing and absorption characteristics from standard gabapentin.
read more about gabapentin enacarbil ...Gabapentin enacarbil treats moderate to severe primary restless legs syndrome in adults. It also treats postherpetic neuralgia in adults, which is persistent nerve pain after shingles. Its safety and efficacy for epilepsy have not been established.
After absorption, the body converts gabapentin enacarbil to gabapentin. The resulting gabapentin affects nerve signaling. The precise way it relieves restless legs symptoms and postherpetic neuralgia is not fully known.
Take the extended-release tablets with food and swallow them whole. For restless legs syndrome, the usual schedule is once daily at about 5 p.m. For postherpetic neuralgia, the usual treatment schedule is different and includes twice-daily dosing.
Sleepiness and dizziness can occur and can affect driving. Opioids, other sedating medicines, or underlying breathing problems can increase the risk of respiratory depression. Kidney problems can require a dose adjustment, and treatment should not be stopped abruptly without medical guidance.
The body converts gabapentin enacarbil to gabapentin, but the products are absorbed differently. Do not substitute one for the other at the same dose.
Food affects how the extended-release product is absorbed. Follow the product directions and take each dose with food.
Its safety and efficacy for epilepsy have not been established. Its labeled uses are restless legs syndrome and postherpetic neuralgia in adults.
The usual schedule is once daily at about 5 p.m. The schedule for postherpetic neuralgia is different.
A randomized, double-blind, placebo-controlled study to assess the efficacy and tolerability of gabapentin enacarbil in subjects with restless legs syndrome. PubMed. https://pubmed.ncbi.nlm.nih.gov/21677899/. Date Accessed October 6, 2026.
Gabapentin. MedlinePlus. https://medlineplus.gov/druginfo/meds/a694007.html. Date Accessed October 6, 2026.
Gabapentin enacarbil (oral route) - Side effects & dosage. Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/gabapentin-enacarbil-oral-route/description/drg-20122596. Date Accessed October 6, 2026.
Gabapentin Enacarbil Extended-Release Tablets. Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/19794-gabapentin-enacarbil-extended-release-tablets. Date Accessed October 6, 2026.
HORIZANT- gabapentin enacarbil tablet, extended release. DailyMed (National Library of Medicine). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4c486fc7-c8c4-4c6c-b30c-366dabaeaadd. Date Accessed October 6, 2026.