What Is Fulvestrant?
Fulvestrant is a prescription hormone therapy for certain advanced breast cancers. It blocks estrogen receptors on cancer cells. It is given as injections into the muscles of the buttocks.
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What Is Fulvestrant Used For?
Fulvestrant treats certain hormone receptor-positive advanced or metastatic breast cancers. It can be used alone in eligible postmenopausal women or with another cancer medicine in specific treatment plans. The choice depends on prior treatment and the characteristics of the cancer.
How Does Fulvestrant Work?
Estrogen can stimulate the growth of breast cancer cells that have estrogen receptors. Fulvestrant binds to those receptors and reduces their activity and abundance. This can slow the growth of cancers that depend on estrogen signaling.
How Is Fulvestrant Given?
A healthcare professional gives fulvestrant as two slow injections, one into each buttock. The first three treatment visits are spaced closer together. Injections are then generally given once a month.
What Are Fulvestrant Side Effects and Precautions?
Injection-site pain, nausea, joint pain, and hot flashes can occur. Tell the care team about bleeding problems, blood-thinning medicines, or liver disease before treatment. Fulvestrant can harm a developing fetus, so pregnancy precautions should be discussed when relevant.
Frequently Asked Questions About Fulvestrant
Is fulvestrant chemotherapy?
No. It is an endocrine treatment that blocks estrogen receptor activity.
Is fulvestrant a pill?
No. A healthcare professional gives it as injections into the muscles of the buttocks.
How frequently are fulvestrant injections given?
After the initial doses on days 1, 15, and 29, treatment is generally given monthly. Follow the schedule set by the cancer team.
Can fulvestrant be combined with another cancer medicine?
Yes. For some advanced breast cancers, it is prescribed with a medicine such as a CDK4/6 inhibitor.
References
Definition of fulvestrant - NCI Drug Dictionary. National Cancer Institute. https://www.cancer.gov/publications/dictionaries/cancer-drug/def/fulvestrant. Date Accessed October 6, 2026.
Fulvestrant. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/drugs/fulvestrant. Date Accessed October 6, 2026.
Fulvestrant (intramuscular route) - Side effects & uses. Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/fulvestrant-intramuscular-route/description/drg-20063966. Date Accessed October 6, 2026.
Fulvestrant Injection. MedlinePlus. https://medlineplus.gov/druginfo/meds/a607031.html. Date Accessed October 6, 2026.
FULVESTRANT injection, solution. DailyMed (National Library of Medicine). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bc7b4eac-3b63-53d2-e053-2995a90ad5e7. Date Accessed October 6, 2026.