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Fidaxomicin is an oral antibiotic used to treat diarrhea caused by Clostridioides difficile, also called C. difficile. It acts mainly in the intestine, where the bacteria cause infection. It is available as tablets and, under the Dificid brand, an oral suspension.
read more about fidaxomicin ...Fidaxomicin treats confirmed or strongly suspected C. difficile-associated diarrhea. The Dificid product is approved for adults and children ages 6 months and older. It is not intended to treat unrelated infections elsewhere in the body.
Fidaxomicin binds to bacterial RNA polymerase and blocks RNA synthesis in C. difficile. This kills susceptible bacteria in the intestine. Only a small amount of the medicine is absorbed into the bloodstream.
Fidaxomicin is taken by mouth, with or without food. The usual adult tablet schedule is twice daily for 10 days. Pediatric treatment depends on age, weight, and whether a tablet or oral suspension is used.
Nausea, vomiting, and abdominal pain can occur. Severe allergic reactions have also been reported. Tell a clinician if diarrhea continues or returns after treatment, since C. difficile infection can recur.
No. It treats diarrhea caused by C. difficile infection. A clinician determines whether that infection is present or strongly suspected.
The Dificid product is approved for children ages 6 months and older. The formulation and dose depend on the child's weight and ability to swallow tablets.
Yes. It can be taken with or without food.
Yes. Symptoms can recur after an initial improvement. Contact the treating clinician if diarrhea returns.
DIFICID (fidaxomicin) tablets and oral suspension: Prescribing Information. DailyMed (National Library of Medicine). https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd966338-c820-4270-b704-09ef75fa3ceb. Date Accessed October 6, 2026.
Fidaxomicin. MedlinePlus. https://medlineplus.gov/druginfo/meds/a611040.html. Date Accessed October 6, 2026.
Fidaxomicin (oral route) - Side effects & dosage. Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/fidaxomicin-oral-route/description/drg-20074965. Date Accessed October 6, 2026.
Fidaxomicin oral tablets. Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/19620-fidaxomicin-oral-tablets. Date Accessed October 6, 2026.
Pseudomembranous colitis - Diagnosis & treatment. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/pseudomembranous-colitis/diagnosis-treatment/drc-20351439. Date Accessed October 6, 2026.