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Excedrin Migraine is an over-the-counter medicine used to treat migraine. Each caplet contains 250 mg acetaminophen, 250 mg aspirin, and 65 mg caffeine. The label classifies acetaminophen and aspirin as pain relievers and caffeine as a pain reliever aid.
read more about excedrin migraine ...Acetaminophen and aspirin reduce pain through different pharmacologic actions, while caffeine acts as a pain reliever aid in the labeled combination. Aspirin is a nonsteroidal anti-inflammatory drug. The three active ingredients are present together in each caplet at fixed strengths.
Current OTC directions are written for adults. Patients younger than 18 are directed to ask a doctor before use. Children and teenagers who have or are recovering from chickenpox or flu-like symptoms should not take the product due the aspirin-associated risk of Reye syndrome.
Adults take two caplets with a glass of water. The label states not to take more than two caplets in 24 hours unless directed by a doctor. If migraine symptoms persist or worsen after the first dose, medical advice is recommended.
Excedrin Migraine carries warnings for severe liver damage from acetaminophen, serious stomach bleeding from aspirin, severe allergic reactions, medication-overuse headache, and excess caffeine intake. Headaches can worsen when the product is used 10 or more days per month. Other acetaminophen-containing medicines are not taken at the same time.
Each caplet contains 250 mg acetaminophen, 250 mg aspirin, and 65 mg caffeine.
Adults take two caplets with water and should not exceed two caplets in 24 hours unless directed by a doctor.
Current labeling directs patients younger than 18 to ask a doctor before use.
Yes. Current labeling warns that headaches can worsen when the product is used 10 or more days per month.
Acetaminophen. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a681004.html. Date Accessed September 30, 2026.
Aspirin. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a682878.html. Date Accessed September 30, 2026.
Caffeine. MedlinePlus. https://www.medlineplus.gov/caffeine.html. Date Accessed September 30, 2026.
DailyMed - EXCEDRIN MIGRAINE (acetaminophen, aspirin, and caffeine) tablet, film coated. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3caa4adf-abe3-67c3-e063-6294a90a87a4. Date Accessed September 30, 2026.
Excedrin Migraine Caplets Drug Facts. https://www.excedrin.com/content/dam/cf-consumer-healthcare/bp-excedrin-v2/en_US/documents/MIGRAINE_DRUGFACTS_0923.pdf. Date Accessed September 30, 2026.