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Etodolac is a prescription nonsteroidal anti-inflammatory drug used for acute pain and for signs and symptoms of osteoarthritis and rheumatoid arthritis. Immediate-release capsules and tablets are available in several strengths. Treatment uses the lowest appropriate dose for the shortest duration consistent with individual treatment goals.
read more about etodolac ...Etodolac has analgesic, anti-inflammatory, and fever-reducing activity. Its mechanism is not fully defined, but it is linked to inhibition of prostaglandin synthesis. Reduced prostaglandin activity decreases inflammatory signaling and pain sensitization in affected tissues.
Etodolac treats acute pain and signs and symptoms of osteoarthritis and rheumatoid arthritis. Acute pain uses short-interval dosing, while arthritis regimens use scheduled daily dosing. Long-term dosing is reviewed after clinical response and adverse reactions are assessed.
For acute pain, the total daily dose is up to 1000 mg, given as 200 mg to 400 mg every six to eight hours. Osteoarthritis or rheumatoid arthritis can start at 300 mg two or three times daily, 400 mg twice daily, or 500 mg twice daily. Doses above 1000 mg daily have not been adequately evaluated.
Etodolac carries boxed warnings for serious cardiovascular thrombotic events and serious gastrointestinal bleeding, ulceration, and perforation. Other concerns include kidney injury, high blood pressure, heart failure, liver injury, severe skin reactions, and anaphylactic reactions. Use during coronary artery bypass graft surgery is contraindicated.
Yes. Etodolac is a nonsteroidal anti-inflammatory drug with analgesic and anti-inflammatory activity.
Etodolac treats acute pain and signs and symptoms of osteoarthritis and rheumatoid arthritis.
Current immediate-release labeling lists a total daily dose up to 1000 mg.
Yes. The boxed warnings concern serious cardiovascular events and serious gastrointestinal bleeding, ulceration, and perforation.
DailyMed - ETODOLAC capsule and tablet, film coated. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cf17926c-ed90-4fd0-80af-ccee084075e8. Date Accessed September 30, 2026.
Etodolac. Drugs and Lactation Database (LactMed). https://www.ncbi.nlm.nih.gov/books/NBK500633/. Date Accessed September 30, 2026.
Etodolac. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548686/. Date Accessed September 30, 2026.
Etodolac. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a692015.html. Date Accessed September 30, 2026.
Etodolac. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Etodolac. Date Accessed September 30, 2026.