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Estradiol is an estrogen hormone. Current prescription oral tablets contain 0.5 mg, 1 mg, or 2 mg of micronized estradiol. Oral labeling includes moderate to severe menopausal vasomotor symptoms, vulvar and vaginal atrophy, female hypoestrogenism, selected palliative cancer uses, and prevention of postmenopausal osteoporosis in selected patients.
read more about estradiol ...Estradiol binds estrogen receptors in responsive tissues and regulates gene transcription. Estrogen receptors are present in reproductive tissues, bone, the hypothalamus, pituitary gland, liver, and other organs. Oral estradiol replaces estrogen activity when endogenous estrogen concentrations are reduced.
Oral estradiol treats moderate to severe menopausal vasomotor symptoms and vulvar or vaginal atrophy and treats hypoestrogenism due to hypogonadism, castration, or primary ovarian failure. Current tablet labeling also includes selected palliative treatment of metastatic breast cancer or advanced androgen-dependent prostate cancer and prevention of postmenopausal osteoporosis.
For menopausal vasomotor symptoms, vulvar and vaginal atrophy, or female hypoestrogenism, a usual starting range is 1 mg to 2 mg daily, adjusted to symptom control. Menopausal treatment can use a cyclic schedule such as three weeks on therapy followed by one week off. Other labeled conditions use different regimens.
Estrogen therapy carries warnings for endometrial cancer, stroke, deep vein thrombosis, pulmonary embolism, breast cancer with estrogen plus progestogen therapy, and probable dementia in older postmenopausal women. Contraindications include unexplained genital bleeding, estrogen-dependent cancer, active or prior thromboembolic disease, liver disease, and specified thrombophilic disorders.
Current prescription tablets come in 0.5 mg, 1 mg, and 2 mg strengths.
Current tablet labeling lists 1 mg to 2 mg daily as a usual initial range.
Yes. Current labeling includes hypoestrogenism due to hypogonadism, castration, or primary ovarian failure.
Yes, but current labeling reserves estrogen for selected women at significant osteoporosis risk when non-estrogen medicines are not appropriate.
DailyMed - ESTRADIOL tablet. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=774ee81b-8e29-46af-ab12-7157f63b443b. Date Accessed September 30, 2026.
Estradiol. Drugs and Lactation Database (LactMed). https://www.ncbi.nlm.nih.gov/books/NBK501296/. Date Accessed September 30, 2026.
Estradiol. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Estradiol. Date Accessed September 30, 2026.
Estrogen. MedlinePlus. https://medlineplus.gov/druginfo/meds/a682922.html. Date Accessed September 30, 2026.
Estrogen Therapy. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK541051/. Date Accessed September 30, 2026.