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Estrace Vaginal Cream is a prescription estrogen medicine containing estradiol 0.01%, equal to 0.1 mg per gram. It is indicated for moderate to severe symptoms of vulvar and vaginal atrophy due to menopause. The cream is placed in the vagina with the supplied applicator.
read more about estrace vaginal cream ...Estradiol is the principal endogenous estrogen during the reproductive years. Estrogens bind nuclear receptors in estrogen-responsive tissues and alter gene transcription. In vaginal tissue after menopause, estrogen treatment restores estrogen-responsive tissue changes associated with reduced estrogen levels.
Estrace Vaginal Cream is used after menopause for moderate to severe vulvar and vaginal atrophy symptoms. Systemic absorption occurs with vaginal use, so systemic estrogen warnings and contraindications are considered during treatment.
The usual initial range is 2 g to 4 g daily for one or two weeks, followed by gradual reduction to one-half of the initial amount for a similar period. After restoration of the vaginal mucosa, a maintenance dose of 1 g one to three times weekly can be used.
Estrace carries boxed warnings covering endometrial cancer, cardiovascular disorders, breast cancer, and probable dementia associated with estrogen therapy. Contraindications include unexplained genital bleeding, breast cancer, estrogen-dependent neoplasia, active or prior deep vein thrombosis or pulmonary embolism, arterial thromboembolic disease, liver disease, specified thrombophilic disorders, and pregnancy.
Estrace Vaginal Cream contains estradiol 0.01%, equal to 0.1 mg per gram.
It treats moderate to severe vulvar and vaginal atrophy symptoms due to menopause.
Current labeling lists 1 g one to three times weekly after restoration of the vaginal mucosa.
Yes. Systemic absorption occurs, so systemic estrogen warnings are considered during treatment.
DailyMed - ESTRACE (estradiol) cream. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dfc41fcd-c5ba-4b25-b647-cf04d3988b3e. Date Accessed September 30, 2026.
ESTRACE Cream (estradiol vaginal cream USP 0.01%) Prescribing Information. AbbVie. https://www.rxabbvie.com/pdf/estrace_pi.pdf. Date Accessed September 30, 2026.
Estradiol. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Estradiol. Date Accessed September 30, 2026.
Estrogen Therapy. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK541051/. Date Accessed September 30, 2026.
Estrogen Vaginal. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a606005.html. Date Accessed September 30, 2026.