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What Is Esophagojejunostomy?

Esophagojejunostomy is a surgical connection between the esophagus and the jejunum, a portion of the small intestine. It is most commonly created after total gastrectomy, when the entire stomach has been removed. The connection restores a pathway for swallowed food to enter the intestinal tract. It is frequently constructed as part of a Roux-en-Y reconstruction.

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What Is Esophagojejunostomy?

Esophagojejunostomy is a surgical connection between the esophagus and the jejunum, a portion of the small intestine. It is most commonly created after total gastrectomy, when the entire stomach has been removed. The connection restores a pathway for swallowed food to enter the intestinal tract. It is frequently constructed as part of a Roux-en-Y reconstruction.

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Why Is Esophagojejunostomy Performed?

The procedure is most commonly performed after total gastrectomy for gastric cancer or another condition requiring removal of the entire stomach. It can also be used in selected complex upper gastrointestinal reconstructions when the stomach cannot serve as the normal conduit. The goal is to maintain continuity between the esophagus and small intestine so oral nutrition remains possible. The reconstruction plan depends on disease, remaining anatomy, nutritional needs, and the other steps of the operation.

How Is Esophagojejunostomy Performed?

After the stomach is removed, the surgeon brings a segment of jejunum up to the lower end of the esophagus without excessive tension or twisting. The esophagus and jejunum are joined with sutures, a circular stapler, a linear stapler, or a combination of techniques. In a Roux-en-Y reconstruction, the intestinal limbs are arranged so food passes through the esophagojejunal connection while biliary and pancreatic secretions join farther downstream. The anastomosis is assessed for blood supply, patency, and leakage before the operation is completed.

What Is Recovery Like After Esophagojejunostomy?

Patients are monitored for anastomotic leakage, infection, swallowing difficulty, return of bowel function, hydration, and nutritional status. Oral intake is introduced gradually after the surgical team determines that the connection is healing appropriately. Eating patterns change permanently after total gastrectomy, so patients generally need smaller, more frequent meals and long-term nutritional monitoring. Vitamin B12, iron, calcium, vitamin D, and other nutrients can require supplementation after stomach removal.

What Are the Risks and Complications?

Possible complications include anastomotic leak, bleeding, infection, pneumonia, bowel obstruction, and delayed recovery of gastrointestinal function. The esophagojejunal connection can later narrow and cause dysphagia or food sticking, sometimes requiring endoscopic dilation. Reflux of intestinal contents, dumping symptoms, weight loss, and nutritional deficiencies can occur after total gastrectomy. A severe leak or failed anastomosis can require drainage, endoscopic treatment, reoperation, or prolonged nutritional support.

Frequently Asked Questions About Esophagojejunostomy

Is esophagojejunostomy commonly performed after total gastrectomy?

Yes. It is a standard way to restore digestive continuity after the entire stomach has been removed.

What is a Roux-en-Y esophagojejunostomy?

It is a reconstruction in which the esophagus is connected to a Roux limb of jejunum and digestive secretions join the food stream farther downstream.

Can an esophagojejunostomy become narrowed?

Yes. Anastomotic stricture can cause dysphagia or difficulty eating and can require endoscopic dilation or another treatment.

Can a person eat normally after esophagojejunostomy?

Oral eating is possible, but meal size and eating patterns usually change after total gastrectomy. Small frequent meals and long-term nutritional monitoring are commonly needed.

References

Hereditary Diffuse Gastric Cancer (PDQ?) ? Health Professional Version. National Cancer Institute. https://www.cancer.gov/publications/pdq/information-summaries/genetics/hereditary-diffuse-gastric-cancer-hp-pdq. Date Accessed August 13, 2026.

A Modified Anastomosis Technique for Esophagojejunostomy in Laparoscopic Total Gastrectomy. PubMed Central (PMC). https://pmc.ncbi.nlm.nih.gov/articles/PMC8789474/. Date Accessed August 13, 2026.

Linear-stapled side-to-side esophagojejunostomy with hand-sewn closure of the common enterotomy after laparoscopic total gastrectomy. PubMed Central (PMC). https://pmc.ncbi.nlm.nih.gov/articles/PMC5360481/. Date Accessed August 13, 2026.

Anastomotic complications after laparoscopic total gastrectomy with esophagojejunostomy constructed by circular stapler (OrVil?) versus linear stapler (overlap method). PubMed. https://pubmed.ncbi.nlm.nih.gov/28488177/. Date Accessed August 13, 2026.

Diet and Nutrition Before and After Your Gastrectomy. Memorial Sloan Kettering Cancer Center. https://www.mskcc.org/cancer-care/patient-education/eating-after-your-gastrectomy. Date Accessed August 13, 2026.