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Eliquis is a prescription anticoagulant containing apixaban, a selective factor Xa inhibitor. Adult indications include stroke prevention in nonvalvular atrial fibrillation, prevention of deep vein thrombosis after hip or knee replacement, treatment of deep vein thrombosis and pulmonary embolism, and reduction of recurrent venous clots.
read more about eliquis ...Apixaban selectively inhibits free and clot-bound factor Xa and prothrombinase activity. Blocking factor Xa decreases thrombin generation and thrombus formation. Apixaban does not directly inhibit platelet aggregation, though reduced thrombin generation indirectly reduces thrombin-induced platelet aggregation.
Eliquis is used in adults for nonvalvular atrial fibrillation and several deep vein thrombosis and pulmonary embolism indications. Current labeling also includes treatment of venous thromboembolism and reduction of recurrent venous thromboembolism in pediatric patients from birth after at least five days of initial anticoagulant therapy.
For most adults with nonvalvular atrial fibrillation, the dose is 5 mg twice daily, with 2.5 mg twice daily used when at least two labeled dose-reduction criteria are present. Adult deep vein thrombosis or pulmonary embolism treatment starts at 10 mg twice daily for seven days, then 5 mg twice daily.
Eliquis carries boxed warnings for increased thrombotic risk after premature discontinuation and spinal or epidural hematoma with neuraxial procedures. Serious or fatal bleeding can occur. Active pathological bleeding and severe hypersensitivity are contraindications. Use is not recommended in patients with prosthetic heart valves or triple-positive antiphospholipid syndrome.
Yes. Apixaban selectively inhibits factor Xa and reduces thrombin generation and clot formation.
Most adults take 5 mg twice daily, with a lower dose used when specified dose-reduction criteria are met.
Treatment starts at 10 mg twice daily for seven days, followed by 5 mg twice daily.
Yes. The boxed warnings cover thrombosis after premature discontinuation and spinal or epidural hematoma.
Apixaban. https://pubmed.ncbi.nlm.nih.gov/29939687/. Date Accessed September 29, 2026.
Apixaban. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. https://www.ncbi.nlm.nih.gov/books/NBK548281/. Date Accessed September 29, 2026.
Apixaban: MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a613032.html. Date Accessed September 29, 2026.
ELIQUIS (Apixaban) Prescribing Information. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a454cd24-0c6d-46e8-b1e4-197388606175. Date Accessed September 29, 2026.
ELIQUIS U.S. Prescribing Information. https://packageinserts.bms.com/pi/pi_eliquis.pdf. Date Accessed September 29, 2026.