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Duopa is a prescription enteral suspension containing carbidopa and levodopa. It treats motor fluctuations in patients with advanced Parkinson disease. Each milliliter contains 4.63 mg carbidopa and 20 mg levodopa, and treatment is administered through a pump into the small intestine during a 16-hour daily infusion.
read more about duopa ...Levodopa crosses the blood-brain barrier and is converted to dopamine in the brain. Carbidopa inhibits peripheral levodopa decarboxylation, leaving more levodopa for transport into the central nervous system. Carbidopa also reduces peripheral effects such as nausea and vomiting related to levodopa conversion outside the brain.
Duopa is indicated for motor fluctuations in patients with advanced Parkinson disease. Before treatment, patients are converted from other levodopa forms to immediate-release oral carbidopa and levodopa. Vitamin B6 levels are checked before treatment and periodically during therapy under the March 2026 labeling.
Duopa is infused over 16 hours each day using a morning dose, a continuous dose, and extra doses when needed for acute off symptoms. Dosing is individualized according to clinical response and tolerability. The maximum recommended daily amount is 2000 mg of levodopa, equal to one cassette per day.
Serious concerns include gastrointestinal and tube-procedure complications, sudden sleep episodes, orthostatic hypotension, hallucinations, compulsive behaviors, depression, dyskinesia, neuropathy, and withdrawal-related hyperpyrexia and confusion. Current labeling also warns about vitamin B6 deficiency and associated seizures. Abrupt discontinuation or rapid dose reduction is avoided.
Duopa treats motor fluctuations in patients with advanced Parkinson disease.
The enteral suspension is administered over a 16-hour daily infusion period.
The maximum is 2000 mg of levodopa, equal to one cassette per day.
Carbidopa and levodopa therapy can reduce vitamin B6 levels, and severe deficiency has been linked to seizures.
Carbidopa. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK554552/. Date Accessed September 29, 2026.
DailyMed - DUOPA (carbidopa and levodopa) enteral suspension. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7066d371-dc6a-0d6f-7bed-e5dd4ee912da. Date Accessed September 29, 2026.
DUOPA (carbidopa and levodopa) Prescribing Information. https://www.rxabbvie.com/pdf/duopa_pi.pdf. Date Accessed September 29, 2026.
Levodopa (L-Dopa). StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK482140/. Date Accessed September 29, 2026.
Levodopa and Carbidopa. MedlinePlus. https://medlineplus.gov/druginfo/meds/a601068.html. Date Accessed September 29, 2026.