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Doxycycline hyclate is a prescription salt form of doxycycline used as a tetracycline-class antibacterial. Current oral products include capsules and tablets containing doxycycline hyclate equivalent to specified amounts of doxycycline. Labeled uses include numerous susceptible bacterial infections, selected alternative treatments, severe acne adjunctive therapy, and malaria prophylaxis.
read more about doxycycline hyclate ...Doxycycline hyclate releases doxycycline, which binds to the bacterial 30S ribosomal subunit and blocks protein synthesis. The resulting activity is primarily bacteriostatic against susceptible organisms. Cross-resistance with other tetracyclines is common, so antibacterial use is reserved for proven or strongly suspected susceptible infections.
Doxycycline hyclate treats selected rickettsial, respiratory, sexually transmitted, ophthalmic, and other bacterial infections. It is also used for anthrax after exposure, selected infections when penicillin is contraindicated, adjunctive treatment of severe acne, and malaria prophylaxis for short-term travelers to areas with specified resistant Plasmodium falciparum strains.
Adults commonly receive 200 mg on the first day as 100 mg every 12 hours, followed by 100 mg daily. More severe infections use 100 mg every 12 hours. Adult malaria prophylaxis uses 100 mg once daily beginning one or two days before travel, throughout travel, and for four weeks after leaving the area.
Doxycycline hyclate can cause permanent tooth discoloration during tooth development, reversible inhibition of bone growth, Clostridioides difficile-associated diarrhea, photosensitivity, intracranial hypertension, severe skin reactions, hypersensitivity, esophagitis, and esophageal ulceration. Taking capsules or tablets with adequate fluid reduces esophageal irritation risk.
Doxycycline hyclate is a salt form that releases the active antibacterial medicine doxycycline.
For numerous infections, the adult first-day dose is 200 mg divided as 100 mg every 12 hours.
Yes. Selected oral products are labeled for malaria prophylaxis in short-term travelers under specific dosing instructions.
Yes. Esophagitis and esophageal ulceration have been reported with oral tetracycline products.
DailyMed - DOXYCYCLINE HYCLATE capsule. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=bed39bae-64c2-44b4-9c95-682ead4e6738. Date Accessed September 25, 2026.
DailyMed - DOXYCYCLINE HYCLATE tablet, delayed release. https://www.dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c2b08332-3256-4658-965a-ede3d973a388. Date Accessed September 25, 2026.
Doxycycline. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a682063.html. Date Accessed September 25, 2026.
Doxycycline Hyclate. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/24390-14-5. Date Accessed September 25, 2026.
Doxycycline Hyclate. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK555888/. Date Accessed September 25, 2026.