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Diprolene Ointment is a prescription super-high-potency topical corticosteroid containing augmented betamethasone dipropionate 0.05%. It is indicated for inflammatory and itchy manifestations of corticosteroid-responsive dermatoses in patients age 13 and older. The ointment is for skin use only and is not for oral, ophthalmic, or intravaginal use.
read more about diprolene ...Betamethasone dipropionate is a potent synthetic corticosteroid. Corticosteroids affect cellular signaling, immune activity, inflammation, and protein regulation, although the precise mechanism in corticosteroid-responsive skin disorders is unknown. Diprolene has super-high topical corticosteroid potency based on vasoconstrictor testing.
Diprolene Ointment is used in patients age 13 and older with corticosteroid-responsive dermatoses that cause inflammation and itching. Use in younger patients is not recommended due increased susceptibility to systemic corticosteroid effects, including suppression of the hypothalamic-pituitary-adrenal axis.
A thin film is applied to affected skin once or twice daily. Treatment stops when control is achieved and is limited to no more than two consecutive weeks and 50 g per week. The ointment is avoided on the face, groin, and underarms and is not used under occlusive dressings unless directed by a physician.
Diprolene can cause reversible hypothalamic-pituitary-adrenal axis suppression and, with excessive exposure, Cushing syndrome or high blood glucose. Local reactions include skin thinning, irritation, burning, folliculitis, stretch marks, and changes in pigmentation. Topical corticosteroids can also increase the risk of cataracts and glaucoma if ocular exposure occurs.
Diprolene Ointment contains augmented betamethasone dipropionate 0.05%, a super-high-potency topical corticosteroid.
A thin film is applied to affected skin once or twice daily.
Current labeling limits treatment to no more than two consecutive weeks.
No. Current labeling directs patients to avoid use on the face, groin, and underarms.
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DailyMed - DIPROLENE (betamethasone dipropionate) ointment. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=0b9543ad-2ca7-430d-aef9-81c376dc2e6c. Date Accessed September 25, 2026.
DIPROLENE Ointment Prescribing Information. U.S. Food and Drug Administration. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/018741s040lbl.pdf. Date Accessed September 25, 2026.