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Diltiazem hydrochloride is a prescription calcium channel blocker. Immediate-release tablets are used for chronic stable angina and angina from coronary artery spasm. Extended-release oral products are used for hypertension and selected angina indications. Doses and schedules differ substantially by formulation.
read more about diltiazem ...Diltiazem inhibits calcium influx through slow channels in cardiac and vascular smooth muscle. Relaxation of vascular smooth muscle lowers peripheral vascular resistance and blood pressure. In the heart, diltiazem slows atrioventricular nodal conduction and can reduce heart rate, while coronary vasodilation contributes to its antianginal activity.
Diltiazem oral products treat chronic stable angina and angina caused by coronary artery spasm. Selected extended-release formulations also treat hypertension, either alone or with other antihypertensive medicines. Immediate-release tablets and extended-release products are not used on the same dosing schedule.
Immediate-release tablets for angina commonly start at 30 mg four times daily before meals and at bedtime. One current extended-release capsule label starts hypertension treatment at 180 mg to 240 mg once daily and angina treatment at 120 mg or 180 mg once daily. Dose titration follows response and tolerability.
Diltiazem can cause slow heart rate, atrioventricular block, low blood pressure, worsening heart failure, edema, dizziness, and liver injury. Contraindications include sick sinus syndrome without a functioning pacemaker, second- or third-degree atrioventricular block without a pacemaker, severe hypotension, and acute myocardial infarction with pulmonary congestion.
Yes. Diltiazem blocks slow calcium channels in cardiac and vascular smooth muscle.
Oral diltiazem treats selected angina conditions, while several extended-release products also treat hypertension.
A common starting regimen is 30 mg four times daily before meals and at bedtime.
Yes. Diltiazem can cause bradycardia and atrioventricular conduction block.
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