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Cyanocobalamin is a form of vitamin B12. Prescription cyanocobalamin injection contains 1000 mcg per mL and is given intramuscularly or subcutaneously. It is used for vitamin B12 deficiency caused by malabsorption, including pernicious anemia and selected gastrointestinal disorders or surgeries that interfere with absorption.
read more about cyanocobalamin ...Vitamin B12 is required for normal blood-cell formation, cell reproduction, nucleoprotein production, and myelin synthesis. After intramuscular or subcutaneous injection, cyanocobalamin is rapidly absorbed and transported to tissues by specific binding proteins. The liver serves as the main storage site for vitamin B12.
Cyanocobalamin injection is used for vitamin B12 deficiency caused by malabsorption. Labeled causes include pernicious anemia, gastrointestinal disease or surgery, sprue, small-bowel bacterial overgrowth, fish tapeworm infestation, and selected pancreatic or intestinal disease. Patients with normal intestinal absorption can use oral vitamin B12 for chronic treatment.
For pernicious anemia, current injection labeling starts with 100 mcg daily for six or seven days by intramuscular or deep subcutaneous injection. After clinical and blood-cell response, 100 mcg is given on alternate days for seven doses, then every three to four days for another two to three weeks, followed by 100 mcg monthly for life.
Parenteral vitamin B12 has been associated with anaphylactic shock and death. Intensive treatment of severe megaloblastic anemia can cause low potassium and sudden death. Cyanocobalamin can worsen optic nerve damage in early Leber disease. Sensitivity to cobalt or vitamin B12 is a contraindication, and serum potassium is checked closely during early treatment of pernicious anemia.
Yes. Cyanocobalamin is a commonly used form of vitamin B12.
It is administered by intramuscular or subcutaneous injection rather than by the intravenous route.
Pernicious anemia interferes with vitamin B12 absorption, so parenteral treatment bypasses the gastrointestinal absorption problem.
Current injection labeling uses 100 mcg monthly after the initial replacement schedule.
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