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Chlorpheniramine maleate is a first-generation antihistamine used for temporary relief of allergy symptoms. A common over-the-counter tablet contains 4 mg. It relieves sneezing, runny nose, itchy or watery eyes, and itching of the nose or throat from hay fever or other upper respiratory allergies.
read more about chlorpheniramine ...Chlorpheniramine acts as a histamine H1 receptor antagonist. It competes with histamine at H1 receptor sites and reduces histamine-mediated symptoms in the nose, eyes, skin, and other tissues. As a first-generation antihistamine, it also enters the central nervous system and can cause drowsiness.
Chlorpheniramine temporarily relieves sneezing, runny nose, itchy or watery eyes, and itching of the nose or throat caused by hay fever or other upper respiratory allergies. The single-ingredient 4 mg tablet is not used to make a child sleepy.
Adults and children age 12 and older take one 4 mg tablet every four to six hours and should not exceed six tablets in 24 hours. Children age 6 to under 12 take half a tablet every four to six hours and should not exceed three whole tablets in 24 hours. Children under 6 should not use the tablet.
Chlorpheniramine can cause drowsiness and reduced alertness. Alcohol, sedatives, and tranquilizers increase this effect. Medical advice is advised before use in people with glaucoma, chronic bronchitis, emphysema, or difficulty urinating due to an enlarged prostate. Excitability can occur, especially in children.
Yes. Chlorpheniramine is a first-generation histamine H1 receptor antagonist.
Adults and children age 12 and older take one tablet every four to six hours, with a six-tablet daily limit.
Yes. Drowsiness can occur, and alcohol or other sedating medicines can increase it.
No. Current over-the-counter labeling states that it should not be used to make a child sleepy.
Antihistamines. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK538188/. Date Accessed September 21, 2026.
Chlorpheniramine. MedlinePlus. https://medlineplus.gov/druginfo/meds/a682543.html. Date Accessed September 21, 2026.
Chlorpheniramine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/2725. Date Accessed September 21, 2026.
DailyMed - ALLERGY (chlorpheniramine maleate) tablet. https://www.dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=0aa4ac07-bd02-46b2-9cf0-0643e0e1a2da. Date Accessed September 21, 2026.
DailyMed - ALLERGY (chlorpheniramine maleate) tablet. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c948e612-a491-4ad0-adb9-cf31ef76e4d8. Date Accessed September 21, 2026.