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Cefixime is a prescription cephalosporin antibacterial used for susceptible bacterial infections. Current U.S. formulations include capsules, tablets, chewable tablets, and oral suspension. Labeled uses include uncomplicated urinary tract infections, otitis media, pharyngitis or tonsillitis, acute exacerbations of chronic bronchitis, and uncomplicated cervical or urethral gonorrhea under formulation-specific instructions.
read more about cefixime ...Cefixime has bactericidal activity through inhibition of bacterial cell wall synthesis. It is stable against certain beta-lactamase enzymes, so selected organisms resistant to some penicillins or cephalosporins remain susceptible. Resistance can arise through altered penicillin-binding proteins, beta-lactamases, or other bacterial mechanisms.
Cefixime treats susceptible uncomplicated urinary tract infections, otitis media, streptococcal pharyngitis or tonsillitis, acute exacerbations of chronic bronchitis, and uncomplicated cervical or urethral gonorrhea. Current labeling includes adults and children age 6 months and older, though the suitable dosage form depends on age, body weight, and infection.
Adults commonly receive 400 mg daily. Uncomplicated cervical or urethral gonorrhea uses a single 400 mg oral dose. Children age 6 months and older generally receive 8 mg per kg daily, subject to product-specific limits. Kidney impairment requires dose adjustment. Oral formulations are not interchangeable in every clinical setting, particularly treatment of otitis media.
Serious hypersensitivity reactions, including anaphylaxis and shock, have occurred with cefixime. Clostridioides difficile-associated diarrhea is another major concern. Kidney impairment requires dose adjustment, and cephalosporins can reduce prothrombin activity in susceptible patients. Elevated carbamazepine levels and increased anticoagulant effects with warfarin have also been reported.
Labeled uses include selected urinary tract, ear, throat, bronchial, and uncomplicated gonococcal infections.
The recommended adult dose is 400 mg daily, with a single 400 mg dose used for uncomplicated cervical or urethral gonorrhea.
Current labeling includes pediatric patients age 6 months and older. Safety and efficacy below 6 months are not established.
Yes. Reduced kidney function requires dose adjustment, including in patients receiving dialysis.
Cefixime. MedlinePlus. https://medlineplus.gov/druginfo/meds/a690007.html. Date Accessed September 21, 2026.
Cefixime. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Cefixime. Date Accessed September 21, 2026.
Cephalosporins. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK551517/. Date Accessed September 21, 2026.
DailyMed - SUPRAX (cefixime) tablet, capsule, chewable tablet, and powder for suspension. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d0fd45bd-7d52-4fa6-a5f7-f46d5651ffa2. Date Accessed September 21, 2026.
SUPRAX (cefixime) Prescribing Information. U.S. Food and Drug Administration. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/202091s005,203195s006lbl.pdf. Date Accessed September 21, 2026.