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Calcitriol is the active hormonal form of vitamin D3 and is available as a prescription oral medicine. Capsules commonly come in 0.25 mcg and 0.5 mcg strengths, while oral solution contains 1 mcg per mL. It is used for selected calcium, parathyroid, and metabolic bone disorders associated with kidney disease or hypoparathyroidism.
read more about calcitriol ...Calcitriol increases intestinal absorption of calcium and influences calcium use in the body. It also affects phosphate balance and parathyroid hormone activity. These actions help correct low calcium and abnormal bone metabolism in selected kidney and parathyroid disorders. Calcitriol acts directly as an active vitamin D metabolite rather than requiring kidney activation.
Calcitriol is used for secondary hyperparathyroidism and metabolic bone disease in selected patients with moderate to severe chronic kidney failure who are not yet on dialysis. It also treats hypocalcemia and metabolic bone disease during chronic dialysis and hypocalcemia associated with postsurgical hypoparathyroidism, idiopathic hypoparathyroidism, or pseudohypoparathyroidism.
Calcitriol dosing is individualized according to the condition, serum calcium, phosphorus, parathyroid hormone levels, and treatment response. Low starting doses are used and adjusted gradually. During dose adjustment, serum calcium is checked frequently. Dialysis, predialysis kidney disease, and hypoparathyroidism each use different dosing schedules under current labeling.
Excess calcitriol can cause high blood calcium, high urinary calcium, and high blood phosphate. Persistent hypercalcemia can lead to soft-tissue calcification, kidney calcification, dehydration, and abnormal heart rhythms. Calcitriol is contraindicated in people with hypercalcemia or vitamin D toxicity. Calcium, phosphorus, kidney function, and related laboratory values require regular monitoring.
Yes. Calcitriol is the hormonally active form of vitamin D3.
Current oral capsule products commonly come in 0.25 mcg and 0.5 mcg strengths.
Yes. Calcium, phosphorus, kidney function, and other laboratory values are checked according to the treated condition.
Yes. Excess exposure can cause hypercalcemia, hypercalciuria, and hyperphosphatemia.
Calcitriol. MedlinePlus. https://medlineplus.gov/druginfo/meds/a682335.html. Date Accessed September 21, 2026.
Calcitriol. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Calcitriol. Date Accessed September 21, 2026.
Calcitriol. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK526025/. Date Accessed September 21, 2026.
DailyMed - CALCITRIOL capsule and solution. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=66a69351-5b09-4368-a9fa-acf81b5ad882. Date Accessed September 21, 2026.
DailyMed - ROCALTROL (calcitriol) capsule and solution. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d1013494-bf62-4e68-9f0c-e6571137f20f. Date Accessed September 21, 2026.