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Bupivacaine is a prescription amide-type local anesthetic used to produce local or regional anesthesia or analgesia. Injection formulations are used for surgery, dental and oral surgery, diagnostic and therapeutic procedures, and selected obstetrical procedures. Concentrations and routes differ according to the type of nerve block or local infiltration being performed.
read more about bupivacaine ...Bupivacaine blocks generation and conduction of nerve impulses. Local anesthetics raise the threshold for electrical excitation, slow nerve impulse propagation, and reduce the rate of rise of the action potential. Sensory loss generally progresses from pain and temperature to touch, proprioception, and skeletal muscle tone as nerve function becomes blocked.
Bupivacaine injection is used for local infiltration and several regional anesthesia techniques, including peripheral nerve, caudal, epidural, and selected ophthalmic or dental blocks. Only the 0.25% and 0.5% concentrations are indicated for obstetrical anesthesia. The 0.75% concentration is not indicated for obstetrical anesthesia, and obstetrical paracervical block is contraindicated.
Bupivacaine dosing depends on the procedure, concentration, injection site, use of epinephrine, patient size, and physical condition. Current labeling describes substantial adult clinical use with single doses up to 175 mg without epinephrine or 225 mg with epinephrine. Total dosing in clinical studies has reached 400 mg during 24 hours, which the label states should not be exceeded.
Excessive blood concentrations or unintended intravascular injection can cause seizures, respiratory arrest, severe low blood pressure, abnormal heart rhythms, cardiac arrest, and death. Methemoglobinemia is another serious risk. Resuscitation equipment and trained personnel are needed when major regional blocks are performed. Bupivacaine is contraindicated in people with hypersensitivity to amide-type local anesthetics.
Yes. Bupivacaine is an amide-type local anesthetic used for local or regional anesthesia and analgesia.
Bupivacaine produces long-lasting anesthesia. Duration varies with concentration, injection site, procedure, and whether epinephrine is included.
Yes. Bupivacaine is used for epidural anesthesia under concentration-specific and procedure-specific dosing instructions.
No. Current labeling states that the 0.75% concentration is not indicated for obstetrical anesthesia.
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Bupivacaine Injection. MedlinePlus. https://medlineplus.gov/druginfo/meds/a625026.html. Date Accessed September 18, 2026.
DailyMed - BUPIVACAINE HYDROCHLORIDE injection, solution. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=bb44c7e1-d911-4788-908f-09b7b271969b. Date Accessed September 18, 2026.
DailyMed - MARCAINE (bupivacaine hydrochloride) injection, solution. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=562f4499-f3b7-4d9e-b022-61172176c883. Date Accessed September 18, 2026.