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Bumetanide is a prescription loop diuretic used for edema associated with congestive heart failure, liver disease, kidney disease, and nephrotic syndrome. Oral tablets come in 0.5 mg, 1 mg, and 2 mg strengths. An injectable form containing 0.25 mg per mL is used intravenously or intramuscularly when oral treatment is impractical or gastrointestinal absorption is impaired.
read more about bumetanide ...Bumetanide acts mainly in the ascending limb of the loop of Henle, where it inhibits sodium reabsorption and also blocks chloride reabsorption. More sodium, chloride, and water then leave the body in urine. Potassium excretion also increases. Oral diuresis begins within about 30 to 60 minutes and has a relatively short duration.
Bumetanide tablets are indicated for edema associated with congestive heart failure, hepatic disease, renal disease, and nephrotic syndrome. Intravenous or intramuscular bumetanide is used when oral administration is impractical or absorption from the gastrointestinal tract is impaired. The medicine is not used in anuria and is avoided during severe electrolyte depletion.
The usual oral total daily dose is 0.5 mg to 2 mg, commonly given as one dose. If the first dose produces an inadequate diuretic response, a second or third dose can be given at four- to five-hour intervals. The labeled oral maximum is 10 mg daily. Parenteral dosing is individualized when injection is needed.
Bumetanide carries a boxed warning for profound diuresis with water and electrolyte depletion. Excessive dosing can cause dehydration, low blood volume, low potassium, circulatory collapse, and thrombosis. Other concerns include changes in kidney function, increased uric acid, hearing impairment, and severe skin reactions. Anuria, hepatic coma, and severe electrolyte depletion are contraindications.
Yes. Bumetanide is a loop diuretic that increases urinary loss of sodium, chloride, and water.
Labeled uses include edema associated with congestive heart failure, liver disease, kidney disease, and nephrotic syndrome.
The usual total daily dose is 0.5 mg to 2 mg, commonly given as a single dose.
Yes. The boxed warning covers profound diuresis with serious water and electrolyte depletion when excessive doses are used.
Bumetanide. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a684051.html. Date Accessed September 18, 2026.
Bumetanide. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Bumetanide. Date Accessed September 18, 2026.
Bumetanide. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK559181/. Date Accessed September 18, 2026.
DailyMed - BUMETANIDE injection, solution. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=681b5e9d-e2c7-4f29-aaad-e06d4a528c11. Date Accessed September 18, 2026.
DailyMed - BUMETANIDE tablet. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a4dd156d-0f17-43d9-bf78-2d358c50681b. Date Accessed September 18, 2026.