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What Is Betaseron?

Betaseron is a prescription interferon beta-1b medicine used for relapsing forms of multiple sclerosis in adults. Labeled forms include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. Betaseron is supplied as a freeze-dried powder for subcutaneous injection after reconstitution with the supplied diluent.

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What Is Betaseron?

Betaseron is a prescription interferon beta-1b medicine used for relapsing forms of multiple sclerosis in adults. Labeled forms include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. Betaseron is supplied as a freeze-dried powder for subcutaneous injection after reconstitution with the supplied diluent.

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How Does Betaseron Affect Immune Signaling?

The exact mechanism of interferon beta-1b in multiple sclerosis is unknown. Interferon beta-1b binds to receptors on human cells and changes expression of proteins involved in immune activity. Reported effects include reduced pro-inflammatory cytokine production, altered antigen presentation, and reduced lymphocyte movement into the central nervous system.

Who Is Treated With Betaseron?

Betaseron is approved for adults with relapsing forms of multiple sclerosis. These forms include clinically isolated syndrome, relapsing-remitting multiple sclerosis, and active secondary progressive disease. Pediatric safety and efficacy have not been established under the current U.S. prescribing information.

How Are Betaseron Injections Increased?

Treatment starts at 0.0625 mg under the skin every other day. The dose rises over six weeks to 0.25 mg every other day starting in week 7. Each dose is prepared from the freeze-dried powder with the supplied diluent. Injection sites are rotated to reduce local reactions.

What Serious Reactions Are Linked to Betaseron?

Serious risks include liver injury, anaphylaxis, depression and suicidal thoughts, worsening heart failure, injection-site necrosis, low white blood cell counts, thrombotic microangiopathy, pulmonary arterial hypertension, seizures, and drug-induced lupus. Injection-site reactions and flu-like symptoms are common. Blood counts, liver tests, and other laboratory values are checked during treatment.

Frequently Asked Questions About Betaseron

What forms of multiple sclerosis does Betaseron treat?

Betaseron treats relapsing forms of multiple sclerosis in adults, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.

How often is Betaseron injected?

Betaseron is injected under the skin every other day after the initial dose is increased over six weeks.

Why are Betaseron injection sites rotated?

Rotating sites reduces repeated trauma to one area and lowers the risk of severe local reactions and tissue damage.

Can Betaseron affect the liver?

Yes. Serious liver injury has occurred, so liver tests and symptoms of hepatic injury are monitored during treatment.

References

BETASERON (interferon beta-1b) Medication Guide. https://labeling.bayerhealthcare.com/html/products/pi/Betaseron_Medication_Guide.pdf. Date Accessed September 16, 2026.

BETASERON (interferon beta-1b) Prescribing Information. https://labeling.bayerhealthcare.com/html/products/pi/Betaseron_PI.pdf. Date Accessed September 16, 2026.

DailyMed - BETASERON (interferon beta-1b) kit. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=66311f74-0472-4fa3-848a-06002ca0def5. Date Accessed September 16, 2026.

How to Take BETASERON. https://www.betaseron.com/why-betaseron/taking-betaseron. Date Accessed September 16, 2026.

Interferon Beta-1b Injection. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a601151.html. Date Accessed September 16, 2026.