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Betamethasone is a synthetic corticosteroid used in several prescription formulations. One topical form, augmented betamethasone dipropionate cream 0.05%, is a high-potency corticosteroid used for inflammatory and itchy skin disorders that respond to corticosteroids in patients age 13 and older. Exact indications and directions differ across betamethasone formulations.
read more about betamethasone ...Corticosteroids affect cellular signaling, immune activity, inflammation, and protein regulation. The precise mechanism of topical betamethasone dipropionate in corticosteroid-responsive skin disorders is not fully defined. Its glucocorticoid activity reduces inflammatory responses in treated skin and relieves symptoms such as redness and itching.
Augmented betamethasone dipropionate cream 0.05% is approved for inflammatory and itchy manifestations of corticosteroid-responsive dermatoses in patients age 13 and older. The label does not name one single skin disease, since several responsive dermatoses fit this category. It is not intended for oral, ophthalmic, or intravaginal use.
A thin film is applied to affected skin once or twice daily. Treatment stops when control is reached. Use should not exceed 50 g per week. The cream is not used with occlusive dressings unless directed by a physician, and use on the face, groin, armpits, or areas with skin atrophy is avoided.
High-potency topical betamethasone can suppress the hypothalamic-pituitary-adrenal axis, especially with large treatment areas, prolonged use, occlusion, or damaged skin. Other risks include skin atrophy, allergic contact dermatitis, cataracts, glaucoma, increased eye pressure, Cushing syndrome, and high blood sugar. Use in patients younger than 13 is not recommended for the augmented cream.
Yes. Betamethasone is a synthetic corticosteroid with strong glucocorticoid activity.
The labeled regimen is a thin film once or twice daily on affected skin.
Contact with the eyes is avoided. Topical corticosteroids have been linked to cataracts, glaucoma, and increased eye pressure.
No. Current labeling does not recommend this high-potency cream in patients younger than 13.
Betamethasone. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/betamethasone. Date Accessed September 16, 2026.
Betamethasone Topical. MedlinePlus. https://medlineplus.gov/druginfo/meds/a682799.html. Date Accessed September 16, 2026.
DailyMed - BETAMETHASONE DIPROPIONATE cream, augmented. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=86994546-929c-4303-89e4-31ba271673cf. Date Accessed September 16, 2026.
DailyMed - BETAMETHASONE DIPROPIONATE cream, augmented. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=75862805-2cfc-fb45-e053-2991aa0a1403. Date Accessed September 16, 2026.
DailyMed - BETAMETHASONE DIPROPIONATE cream. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5683885d-461c-4e7e-bbe8-dc231d706192. Date Accessed September 16, 2026.