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Benazepril is a prescription angiotensin-converting enzyme inhibitor used to treat high blood pressure. It is converted in the body to benazeprilat, its active metabolite. Tablets come in several strengths and are used alone or with other antihypertensive medicines. Current labeling includes adults and pediatric patients age 6 and older who meet kidney function criteria.
read more about benazepril ...Benazeprilat inhibits angiotensin-converting enzyme, which reduces conversion of angiotensin I into angiotensin II. Lower angiotensin II activity reduces blood vessel constriction and aldosterone secretion. These effects lower vascular resistance and blood pressure. Reduced aldosterone activity can also raise serum potassium.
Benazepril is approved for hypertension. Adults can take it alone or with a thiazide diuretic. Pediatric use includes patients age 6 and older with a glomerular filtration rate above 30 mL per minute per 1.73 square meters. Safety and efficacy are not established in younger children or children below that kidney function threshold.
Adults not taking a diuretic commonly start at 10 mg once daily. The usual maintenance range is 20 mg to 40 mg daily as one dose or two divided doses. Adults with markedly reduced kidney function start at 5 mg once daily. Pediatric dosing starts at 0.2 mg per kg once daily under labeled criteria.
Benazepril carries a boxed warning for fetal toxicity and is stopped when pregnancy is detected. Other serious concerns include angioedema, kidney impairment, low blood pressure, high potassium, and rare liver failure. Kidney function and serum potassium are checked during treatment. Benazepril is contraindicated with a neprilysin inhibitor within the specified 36-hour separation period.
Yes. Benazepril is converted to benazeprilat, which inhibits angiotensin-converting enzyme.
Benazepril is approved for treatment of high blood pressure in adults and eligible pediatric patients.
Yes. Adults with markedly reduced kidney function start at a lower dose.
Yes. The boxed warning covers fetal toxicity, including injury and death to a developing fetus.
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