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Bactrim is a prescription antibacterial combining sulfamethoxazole and trimethoprim. A regular tablet contains 400 mg of sulfamethoxazole and 80 mg of trimethoprim, while Bactrim DS contains 800 mg and 160 mg. Labeled uses include selected urinary, respiratory, intestinal, ear, and Pneumocystis jirovecii infections under specific patient and organism criteria.
read more about bactrim ...Sulfamethoxazole blocks bacterial production of dihydrofolic acid by competing with para-aminobenzoic acid. Trimethoprim blocks conversion of dihydrofolic acid into tetrahydrofolic acid through inhibition of dihydrofolate reductase. Together, the two ingredients interrupt consecutive steps in bacterial folate metabolism needed for nucleic acid and protein production, producing broader antibacterial activity than either ingredient alone.
Bactrim is labeled for selected urinary tract infections, shigellosis, acute exacerbations of chronic bronchitis in adults, acute otitis media in children, and traveler's diarrhea in adults. It also treats Pneumocystis jirovecii pneumonia and is used for prophylaxis in people at increased risk. Use depends on organism susceptibility, age, kidney function, and other patient factors.
Adult urinary tract infection treatment commonly uses one Bactrim DS tablet every 12 hours for 10 to 14 days. Shigellosis uses the same adult dose for five days, while acute exacerbations of chronic bronchitis use the same dose for 14 days. Pneumocystis jirovecii regimens use higher weight-based dosing. Kidney impairment can require dose adjustment.
Serious reactions include Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS, liver necrosis, severe blood disorders, lung injury, anaphylaxis, circulatory shock, high potassium, and low sodium. Bactrim is contraindicated in infants younger than 2 months. A new rash or other sign of a serious reaction calls for immediate discontinuation and medical evaluation. Kidney impairment can increase toxicity risk.
Bactrim combines sulfamethoxazole with trimethoprim in fixed-dose oral tablets that block consecutive steps in bacterial folate metabolism.
Yes. Bactrim is labeled for selected urinary tract infections caused by susceptible bacteria in adults and pediatric patients.
Bactrim DS contains 800 mg of sulfamethoxazole and 160 mg of trimethoprim, twice the amount in a regular Bactrim tablet.
No. Bactrim is contraindicated in infants younger than 2 months under current U.S. labeling.
BACTRIM (sulfamethoxazole and trimethoprim) Tablets Prescribing Information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/017377s084lbl.pdf. Date Accessed September 15, 2026.
Co-trimoxazole. MedlinePlus. https://medlineplus.gov/druginfo/meds/a684026.html. Date Accessed September 15, 2026.
DailyMed - BACTRIM and BACTRIM DS (sulfamethoxazole and trimethoprim) tablets. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f59d0c04-9c66-4d53-a0e1-cb55570deb62. Date Accessed September 15, 2026.
DailyMed - SULFAMETHOXAZOLE AND TRIMETHOPRIM tablet. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4833319a-a7b3-4bf4-bec4-6531b43182d4. Date Accessed September 15, 2026.
Trimethoprim-Sulfamethoxazole. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK513232/. Date Accessed September 15, 2026.