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Azilect is a prescription medicine containing rasagiline, a selective monoamine oxidase B inhibitor used for Parkinson disease. It can be used alone or with other Parkinson medicines, including levodopa. Tablets come in 0.5 mg and 1 mg strengths and are taken once daily. Liver function and interacting medicines affect dose selection.
read more about azilect ...Rasagiline irreversibly inhibits monoamine oxidase B, an enzyme involved in dopamine metabolism in the brain. Inhibiting this enzyme reduces dopamine breakdown and increases dopaminergic activity. This action contributes to improvement in Parkinson symptoms when rasagiline is used alone or together with levodopa and other Parkinson medicines.
Azilect is approved for treatment of Parkinson disease. It is used as monotherapy, as adjunct therapy without levodopa, or as adjunct therapy with levodopa. Patients taking levodopa start with a lower rasagiline dose and can increase after clinical review when symptom control remains inadequate.
Monotherapy and adjunct treatment without levodopa use 1 mg once daily. When taken with levodopa, treatment starts at 0.5 mg once daily and can increase to 1 mg daily. Patients taking ciprofloxacin or another CYP1A2 inhibitor should not exceed 0.5 mg daily. Mild liver impairment also uses a 0.5 mg daily limit.
Azilect can cause high blood pressure, serotonin syndrome, sudden sleep episodes, daytime sleepiness, low blood pressure, dyskinesia, hallucinations, and compulsive behaviors. It is contraindicated with several medicines, including meperidine, tramadol, methadone, dextromethorphan, cyclobenzaprine, St. John's wort, and other MAO inhibitors. Moderate or severe liver impairment is also a reason to avoid Azilect.
Yes. Azilect contains rasagiline, an irreversible monoamine oxidase B inhibitor used for Parkinson disease.
Azilect is taken once daily. The dose is 0.5 mg or 1 mg depending on the treatment regimen and patient factors.
Yes. Azilect is approved as adjunct therapy with levodopa, with a starting dose of 0.5 mg once daily.
No. Dextromethorphan is contraindicated with Azilect due to the risk of psychosis or unusual behavior.
AZILECT (rasagiline) Prescribing Information. https://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=a40d0e73-3f9f-4b01-979d-402c9cdaeb60&type=pdf. Date Accessed September 15, 2026.
DailyMed - AZILECT (rasagiline mesylate) tablet. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a40d0e73-3f9f-4b01-979d-402c9cdaeb60. Date Accessed September 15, 2026.
DailyMed - RASAGILINE tablet. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9bf059f4-4da8-48fe-aacb-c50717d36606. Date Accessed September 15, 2026.
Rasagiline. MedlinePlus. https://medlineplus.gov/druginfo/meds/a606017.html. Date Accessed September 15, 2026.
Rasagiline Mesylate. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/161735-79-1. Date Accessed September 15, 2026.