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Aspirin is a salicylate and nonsteroidal anti-inflammatory drug used for temporary relief of minor pain and fever. Common over-the-counter tablets contain 81 mg or 325 mg. Clinicians also direct aspirin use for its antiplatelet action in selected cardiovascular settings. Product strength, release form, reason for use, age, and medical history shape the dosing instructions.
read more about aspirin ...Aspirin inhibits cyclooxygenase enzymes and reduces production of prostaglandins involved in pain, fever, and inflammation. It also irreversibly inhibits platelet cyclooxygenase, reducing formation of thromboxane A2, a substance involved in platelet aggregation and blood vessel constriction. The platelet effect lasts for the life of the affected platelet.
Regular-strength 325 mg aspirin is used for temporary relief of headache, muscle pain, minor arthritis pain, toothache, menstrual pain, and pain or fever from colds. Low-dose aspirin is also taken under clinician direction for selected antiplatelet uses. Delayed-release 81 mg products act too slowly for rapid relief of headaches or similar symptoms.
For a 325 mg over-the-counter tablet, adults and children age 12 and older take one or two tablets every four hours or three tablets every six hours. The label limits use to 12 tablets in 24 hours unless a doctor directs otherwise. Each dose is taken with a full glass of water.
Aspirin can cause severe stomach bleeding and serious allergic reactions. Children and teenagers recovering from chickenpox or flu-like illness should not use aspirin due to Reye syndrome risk. Ringing in the ears can signal toxicity. Pregnancy, kidney disease, liver disease, asthma, bleeding disorders, anticoagulant use, and other NSAID use call for medical review before treatment.
Yes. Aspirin is a nonsteroidal anti-inflammatory drug with pain-relieving, fever-reducing, anti-inflammatory, and antiplatelet actions.
Yes. Aspirin irreversibly inhibits platelet cyclooxygenase and reduces thromboxane A2 formation, which decreases platelet aggregation.
Children and teenagers with chickenpox or flu-like symptoms should not use aspirin due to the risk of Reye syndrome.
A common regular-strength over-the-counter aspirin tablet contains 325 mg.
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Aspirin for Reducing Your Risk of Heart Attack and Stroke: Know the Facts. U.S. Food and Drug Administration. https://www.fda.gov/drugs/safe-use-aspirin/aspirin-reducing-your-risk-heart-attack-and-stroke-know-facts. Date Accessed September 14, 2026.
DailyMed - ASPIRIN 81 MG tablet, delayed release. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=468f4a2f-60f7-4808-95d7-a00be1bb112f. Date Accessed September 14, 2026.
DailyMed - ASPIRIN tablet, film coated, 325 mg. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=18e00303-9db1-4f70-a4f1-8b590fa959d7. Date Accessed September 14, 2026.
Salicylic Acid (Aspirin). StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK519032/. Date Accessed September 14, 2026.