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Apriso is a prescription extended-release mesalamine medicine in the aminosalicylate class. It is approved for maintenance of remission of ulcerative colitis in adults. Each capsule contains 0.375 g of mesalamine in extended-release granules. The labeled adult dose is 1.5 g once daily in the morning, equal to four capsules.
read more about apriso ...The exact mechanism of mesalamine is not fully known. Its action appears to be a local anti-inflammatory effect on cells lining the colon. Mesalamine is thought to reduce inflammation partly by decreasing production of arachidonic acid metabolites, including prostanoids and leukotrienes, that are elevated in ulcerative colitis.
Apriso is approved for adults who need maintenance treatment to keep ulcerative colitis in remission. Its U.S. indication is maintenance of remission rather than induction treatment for active ulcerative colitis. Kidney function is checked before treatment and periodically during therapy due the risk of renal injury.
The recommended adult dose is four 0.375 g capsules once daily in the morning, for a total of 1.5 g. Capsules are swallowed whole and should not be cut, broken, crushed, or chewed. Apriso can be taken without regard to meals. Antacids are avoided, and patients are advised to drink adequate fluids.
Risks include kidney impairment, mesalamine-induced acute intolerance syndrome, hypersensitivity reactions, liver failure in people with liver disease, severe skin reactions, photosensitivity, and kidney stones. Each capsule contains phenylalanine from aspartame, which matters for people with phenylketonuria. New abdominal pain, bloody diarrhea, rash, fever, or reduced kidney function calls for medical review.
Apriso is approved to maintain remission of ulcerative colitis in adults. Its label does not list induction of remission as an indication.
The labeled adult dose is four 0.375 g capsules once daily in the morning.
No. Apriso capsules are swallowed whole and should not be cut, broken, crushed, or chewed.
Yes. Apriso can be taken without regard to meals.
APRISO (mesalamine) Extended-Release Capsules Prescribing Information. https://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=7951139c-b271-45a4-b523-34b23800917b&type=pdf. Date Accessed September 14, 2026.
DailyMed - APRISO (mesalamine) capsule, extended release. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7951139c-b271-45a4-b523-34b23800917b. Date Accessed September 14, 2026.
FDA Label - APRISO (mesalamine) Extended-Release Capsules. https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/022301s022lbl.pdf. Date Accessed September 14, 2026.
Mesalamine. MedlinePlus. https://medlineplus.gov/druginfo/meds/a688021.html. Date Accessed September 14, 2026.
Mesalamine. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK551714/. Date Accessed September 14, 2026.