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A rho kinase inhibitor is a medicine that blocks rho kinase, an enzyme involved in cell shape, contraction, and tissue resistance. In eye care, rho kinase inhibitor drops are used to lower intraocular pressure in open-angle glaucoma or ocular hypertension. Netarsudil is the main ophthalmic medicine in this class. It helps fluid leave the eye through the trabecular meshwork, the eye's conventional drainage pathway.
read more about rho kinase inhibitor ...Rho kinase inhibition relaxes tissues in the trabecular meshwork and Schlemm's canal. This can reduce resistance to aqueous humor outflow. Netarsudil can also lower episcleral venous pressure and reduce fluid production to a smaller degree. The combined effect helps lower eye pressure.
Eye doctors prescribe rho kinase inhibitors for patients with open-angle glaucoma or ocular hypertension. They can be used alone or with other pressure-lowering medicines. Some patients use netarsudil when pressure is not at goal on another drop. The doctor decides based on eye pressure, optic nerve status, tolerability, and treatment history.
Netarsudil ophthalmic solution is sold as Rhopressa. A fixed-combination product pairs netarsudil with latanoprost in one bottle. These drops are prescription medicines and are not interchangeable with other glaucoma drops. Patients should follow the dosing directions on the label and from the prescriber.
Rho kinase inhibitor drops can cause eye redness, instillation-site pain, corneal verticillata, and small conjunctival bleeding spots. They can also cause tearing, blurred vision, or irritation. Corneal verticillata is a whorl-like corneal finding that the eye doctor can monitor during treatment. Report severe pain, sudden vision changes, worsening redness, or signs of allergy right away.
Yes, netarsudil is a rho kinase inhibitor used to lower eye pressure. It is prescribed for open-angle glaucoma or ocular hypertension.
No, rho kinase inhibitors do not cure glaucoma. They help lower eye pressure as part of ongoing glaucoma management.
Eye redness can happen because rho kinase inhibitors affect blood vessels on the eye surface. The redness can be mild for some patients and more noticeable for others.
Yes, they can be used with other glaucoma medicines when an eye doctor prescribes that plan. The schedule should be followed carefully so doses are not missed or doubled.
Label: RHOPRESSA- netarsudil solution/drops. DailyMed. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7d4f0e3a-5b86-4c43-982a-813b22ae7e22. Date Accessed June 3, 2026.
Label: ROCKLATAN- netarsudil and latanoprost solution/drops. DailyMed. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b1d71f41-be06-4a08-94d4-e352198f09c2. Date Accessed June 3, 2026.
Netarsudil (ophthalmic route). Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/netarsudil-ophthalmic-route/description/drg-20406675. Date Accessed June 3, 2026.
Netarsudil Ophthalmic Solution. StatPearls (NCBI Bookshelf). https://www.ncbi.nlm.nih.gov/books/NBK572105/. Date Accessed June 3, 2026.
Netarsudil Ophthalmic: MedlinePlus Drug Information. MedlinePlus. https://medlineplus.gov/druginfo/meds/a618014.html. Date Accessed June 3, 2026.